The amino acid sensor general control nonderepressible 2 (GCN2) controls T(H)9 cells and allergic airway inflammation

摘要

Background: T(H)9 cells have emerged as important mediators of allergic airway inflammation. There is evidence that general control nonderepressible 2 (GCN2) affects the immune response under some stress conditions. However, whether GCN2 regulates CD4(+) T-cell differentiation during allergic inflammation remains unknown.