Palladium-catalyzed oxamidation of alkenes: A new approach to benzoxazolidines

摘要

A novel palladium catalyzed protocol for the synthesis of benzoxazolidine by the reaction sulfamido-phenol and terminal alkene was developed. This oxamidation process is simple and does not require any ligand, base or inert atmosphere for the overall transformation. From control experiments, it is apparent that the cross-coupling reaction proceeds with initial formation of enesulfonamide which undergoes nucleopalladation by the intramolecular annulation and subsequent protodepalladation by TsOH to afford the benzoxazolidine. (C) 2018 Elsevier Ltd. All rights reserved.