Synthesis of the diarylindolizidine alkaloid (+)-Fistulopsine B: Application of an organocatalytic Michael addition reaction

摘要

The first synthesis of a recently isolated antiproliferative diarylindolizidine alkaloid, (+)-fistulopsine B, was achieved. The synthesis features the use of an organocatalytic ketone-nitrostyrene Michael addition as the key step. (C) 2018 Elsevier Ltd. All rights reserved.