NOVEL TRIAL DESIGN TO EVALUATE ORAL VOXELOTOR FOR THE TREATMENT OF SICKLE CELL DISEASE: PROTOCOL OF THE PHASE 3 HEMOGLOBIN OXYGEN AFFINITY MODULATION TO INHIBIT SICKLE HEMOGLOBIN POLYMERIZATION (HOPE) TRIAL (GBT440-031)

Hoppe Carolyn; Ataga Kenneth; Ware Russell; Howard Jo; Tonda Margaret; Ganju Jitendra; Lehrer Josh

首页> 外文期刊>Pediatric blood & cancer >NOVEL TRIAL DESIGN TO EVALUATE ORAL VOXELOTOR FOR THE TREATMENT OF SICKLE CELL DISEASE: PROTOCOL OF THE PHASE 3 HEMOGLOBIN OXYGEN AFFINITY MODULATION TO INHIBIT SICKLE HEMOGLOBIN POLYMERIZATION (HOPE) TRIAL (GBT440-031)

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NOVEL TRIAL DESIGN TO EVALUATE ORAL VOXELOTOR FOR THE TREATMENT OF SICKLE CELL DISEASE: PROTOCOL OF THE PHASE 3 HEMOGLOBIN OXYGEN AFFINITY MODULATION TO INHIBIT SICKLE HEMOGLOBIN POLYMERIZATION (HOPE) TRIAL (GBT440-031)

机译：新型试验设计评估口服毒素治疗镰状细胞疾病：第3期血红蛋白氧亲和力调节的方案抑制镰刀血红蛋白聚合（HOPE）试验（GBT440-031）

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来源
《Pediatric blood & cancer》 |2018年第1期|共1页
作者
Hoppe Carolyn; Ataga Kenneth; Ware Russell; Howard Jo; Tonda Margaret; Ganju Jitendra; Lehrer Josh;
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作者单位

Global Blood Therapeut San Francisco CA USA;

Global Blood Therapeut San Francisco CA USA;

Global Blood Therapeut San Francisco CA USA;

Global Blood Therapeut San Francisco CA USA;

Global Blood Therapeut San Francisco CA USA;

Global Blood Therapeut San Francisco CA USA;

Global Blood Therapeut San Francisco CA USA;

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正文语种 eng
中图分类儿科学;
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1. NOVEL TRIAL DESIGN TO EVALUATE ORAL VOXELOTOR FOR THE TREATMENT OF SICKLE CELL DISEASE: PROTOCOL OF THE PHASE 3 HEMOGLOBIN OXYGEN AFFINITY MODULATION TO INHIBIT SICKLE HEMOGLOBIN POLYMERIZATION (HOPE) TRIAL (GBT440-031) [J] . Hoppe Carolyn, Ataga Kenneth, Ware Russell, Pediatric blood & cancer . 2018,第Suppla1期

机译：新型试验设计评估口服毒素治疗镰状细胞疾病：第3期血红蛋白氧亲和力调节的方案抑制镰刀血红蛋白聚合（HOPE）试验（GBT440-031）
2. NOVEL TRIAL DESIGN TO EVALUATE ORAL VOXELOTOR FOR THE TREATMENT OF SICKLE CELL DISEASE: PROTOCOL OF THE PHASE 3 HEMOGLOBIN OXYGEN AFFINITY MODULATION TO INHIBIT SICKLE HEMOGLOBIN POLYMERIZATION (HOPE) TRIAL (GBT440-031) [J] . Hoppe Carolyn, Ataga Kenneth, Ware Russell, Pediatric blood & cancer . 2018,第Suppla1期

机译：新型试验设计评估口服毒素治疗镰状细胞疾病：第3期血红蛋白氧亲和力调节的方案抑制镰刀血红蛋白聚合（HOPE）试验（GBT440-031）
3. Results from Part A of the Hemoglobin Oxygen Affinity Modulation to Inhibit HbS Polymerization (HOPE) Trial (GBT440-031), a Placebo-Controlled Randomized Study Evaluating Voxelotor (GBT440) in Adults and Adolescents with Sickle Cell Disease [J] . Vichinsky Elliott, Hoppe Carolyn, Howard Jo, Blood: The Journal of the American Society of Hematology . 2018,第NovaelaTreatmentAppr期

机译：血红蛋白氧亲和力调节的一部分A抑制HBS聚合（HPS）试验（GBT440-031），一种安慰剂对照随机研究评估体内和镰状细胞病的青少年中的毒素（GBT440）
4. Control of the nucleation of sickle cell hemoglobin polymers by free hematin [C] . Veselina Uzunova, Weichun Pan, Vassiliy Lubchenko, General Discussion on Crystallisation . 2012

机译：通过游离血管控制镰状细胞血红蛋白聚合物的成核
5. Lipid Peroxidation in Sickle Cell Disease: The Contribution of Cell-Free Hemoglobin in Plasma. [D] . Flewelen, Timothy. 2012

机译：镰状细胞病中的脂质过氧化作用：血浆中无细胞血红蛋白的贡献。
6. Voxelotor: A Hemoglobin S Polymerization Inhibitor for the Treatment of Sickle Cell Disease [O] . Avani Yenamandra, Dennis Marjoncu 2020

机译：Voxelotor：用于治疗镰状细胞疾病的血红蛋白S聚合抑制剂
7. EFFECTS OF ATHROSPIRA PLATENSIS, MONODORA MYRISTICA AND HELIANTHUS ANNUUS ON THE RATE OF POLYMERIZATION, SICKLE CELL REVERSION AND OXYGEN AFFINITY OF SICKLE CELL HEMOGLOBIN [O] . Nwaichi E. O., Monago C.C., Amaraegbulem P. I. 2013

机译：动脉粥样硬化，单枝单胞菌和向日葵对聚合细胞，ICK细胞再生和AND细胞血红蛋白氧亲合力的影响

NOVEL TRIAL DESIGN TO EVALUATE ORAL VOXELOTOR FOR THE TREATMENT OF SICKLE CELL DISEASE: PROTOCOL OF THE PHASE 3 HEMOGLOBIN OXYGEN AFFINITY MODULATION TO INHIBIT SICKLE HEMOGLOBIN POLYMERIZATION (HOPE) TRIAL (GBT440-031)

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