Novel Protamine-Based Polyelectrolyte Carrier Enhances Low-Dose rhBMP-2 in Posterolateral Spinal Fusion

Hu Tao; Abbah Sunny Akogwu; Wang Ming; Toh Soo Yein; Lam Raymond Wing Moon; Naidu Mathanapriya; Bhakta Gajadhar; Cool Simon M.; Bhakoo Kishore; Li Jun; Goh James Cho-Hong; Wong Hee-Kit

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Novel Protamine-Based Polyelectrolyte Carrier Enhances Low-Dose rhBMP-2 in Posterolateral Spinal Fusion

机译：新型苯胺胺基聚电解质载体在后侧脊柱融合中增强低剂量rhBMP-2

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摘要

Study Design. A rodent posterolateral spinal fusion model.

机译：学习规划。啮齿动物后侧脊柱融合模型。

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来源
《Spine》 |2015年第9期|共9页
作者
Hu Tao; Abbah Sunny Akogwu; Wang Ming; Toh Soo Yein; Lam Raymond Wing Moon; Naidu Mathanapriya; Bhakta Gajadhar; Cool Simon M.; Bhakoo Kishore; Li Jun; Goh James Cho-Hong; Wong Hee-Kit;
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作者单位

Natl Univ Singapore Yong Loo Lin Sch Med Dept Orthopaed Surg Singapore 117595 Singapore;

Natl Univ Singapore Yong Loo Lin Sch Med Dept Orthopaed Surg Singapore 117595 Singapore;

Natl Univ Singapore Yong Loo Lin Sch Med Dept Orthopaed Surg Singapore 117595 Singapore;

Natl Univ Singapore Yong Loo Lin Sch Med Dept Orthopaed Surg Singapore 117595 Singapore;

Natl Univ Singapore Yong Loo Lin Sch Med Dept Orthopaed Surg Singapore 117595 Singapore;

Natl Univ Singapore Yong Loo Lin Sch Med Dept Orthopaed Surg Singapore 117595 Singapore;

ASTAR Inst Med Biol Singapore Singapore;

Natl Univ Singapore Yong Loo Lin Sch Med Dept Orthopaed Surg Singapore 117595 Singapore;

Natl Univ Singapore Yong Loo Lin Sch Med Dept Orthopaed Surg Singapore 117595 Singapore;

Natl Univ Singapore Fac Engn Dept Biomed Engn Singapore 117548 Singapore;

Natl Univ Singapore Yong Loo Lin Sch Med Dept Orthopaed Surg Singapore 117595 Singapore;

Natl Univ Singapore Yong Loo Lin Sch Med Dept Orthopaed Surg Singapore 117595 Singapore;

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原文格式 PDF
正文语种 eng
中图分类骨科学（运动系疾病、矫形外科学）;
关键词
protamine; heparin; polyelectrolyte complex; posterolateral spinal fusion; low dose; recombinant human bone morphogenetic protein 2; acellular; bone tissue engineering; control release; absorbable collagen sponge; growth factor carrier;

机译：protamine;肝素;聚电解质复合物;后外侧脊柱融合;低剂量;重组人骨形态发生蛋白2;无细胞;骨组织工程;控制释放;可吸收的胶原海绵;生长因子载体;

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专利

1. Novel Protamine-Based Polyelectrolyte Carrier Enhances Low-Dose rhBMP-2 in Posterolateral Spinal Fusion [J] . Hu Tao, Abbah Sunny Akogwu, Wang Ming, Spine . 2015,第9期

机译：新型基于鱼精蛋白的聚电解质载体增强后外侧脊柱融合术中的低剂量rhBMP-2
2. Enhancement of posterolateral lumbar spine fusion using low-dose rhBMP-2 and cultured marrow stromal cells. [J] . Fu TS, Chen WJ, Chen LH, Journal of orthopaedic research . 2009,第3期

机译：使用低剂量rhBMP-2和培养的骨髓基质细胞增强后外侧腰椎融合。
3. Bone marrow-derived mesenchymal stem cells assembled with low-dose BMP-2 in a three-dimensional hybrid construct enhances posterolateral spinal fusion in syngeneic rats [J] . Hu Tao, Abbah Sunny Akogwu, Toh SooYein, The spine journal: official journal of the North American Spine Society . 2015,第12期

机译：三维混合构建体中低剂量BMP-2组装的骨髓源间充质干细胞增强了同系大鼠的后外侧脊柱融合
4. Modulation of rhBMP-2 from Polyelectrolyte Complexation Microbeads System Enhanced In Vivo Bone Formation in a Spinal Fusion Model [C] . Hu Tao, Abbah Sunny-Akogwu, James Goh, World biomaterials congress . 2012

机译：聚合电解质络合微珠系统对rhBMP-2的调节增强了脊柱融合模型体内的骨形成。
5. Human Perivascular Stem Cells and Nel-like protein-1 Synergistically Enhance Spinal Fusion in Osteoporotic Rats. [D] . Girgius, Caroline Magdy Mikhael. 2016

机译：人血管周围干细胞和Nel样蛋白1协同增强骨质疏松大鼠的脊髓融合。
6. Injectable and compression-resistant low-viscosity polymer/ceramic composite carriers for rhBMP-2 in a rabbit model of posterolateral fusion: a pilot study [O] . Stefanie M. Shiels, Anne D. Talley, Madison A. P. McGough, 2017

机译：兔后外侧融合模型中rhBMP-2的可注射且抗压低粘度聚合物/陶瓷复合载体的初步研究
7. PSU16 Retrospective Analysis of Cost Outcomes for Patients Receiving Infuse Bone Graft (rhBMP-2) or Actifuse Bone Graft Substitute (Si-CaP) During Posterolateral Spinal Fusion [O] . Magee G., Boatright A., Hagerman E., 2012

机译：PSU16回顾性分析后外侧脊柱融合术中接受输注骨移植（rhBMP-2）或Actifuse骨移植替代品（Si-CaP）的患者的费用结果
8. Effects of rhBMP-2 Used for Spinal Fusion on Spinal Cord Pathology After Traumatic Injury [R] . Dmitriev, A. E. 2009

机译：rhBmp-2用于脊柱融合对创伤后脊髓病理的影响

Novel Protamine-Based Polyelectrolyte Carrier Enhances Low-Dose rhBMP-2 in Posterolateral Spinal Fusion

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