Synthesis of Forms of a Chiral Ruthenium Complex Containing a Ru-C-olefin(sp(2)) Bond and Their Application to Catalytic Asymmetric Cyclopropanation Reactions

摘要

Organometallic complexes [Ru-C-olefin(sp(2))-Ru(II)-Pheox 2a-2d] containing a Ru-C-olefin(SP2) bond have been prepared from unsaturated chiral oxazoline derivatives and evaluated for asymmetric cyclopropanation reactions. The corresponding optically active cyclopropanes were obtained with high yields and high stereoselectivities (>= 99/<1 trans/cis, 99% trans ee). The enantiose-lectivities were found to be affected by the geminal substituent on the Ru-C(sp(2)) bond. In particular, Ru(II)-Prox catalyst 2c, in which there was no geminal substituent on the metal, was shown to have the highest enantioselectivities.