The dopamine and glutamate theories of schizophrenia: A short review

摘要

Schizophrenia is a psychiatric disorder involving the impairment of normal thinking, emotion, and everyday behaviours. Characteristics of schizophrenia can be divided into positive, negative and cognitive symptoms. Contributory factors of the disorder include genetics, early environmental factors and neuropsychological factors. Many years of research has investigated the dopamine hypothesis and glutamate hypothesis of schizophrenia, but more recently the field is scrutinizing the combined interactions of the glutamatergic and dopaminergic systems.