HOPON (Hyperbaric Oxygen for the Prevention of Osteoradionecrosis): A Randomized Controlled Trial of Hyperbaric Oxygen to Prevent Osteoradionecrosis of the Irradiated Mandible After Dentoalveolar Surgery

Shaw Richard J.; Butterworth Christopher J.; Silcocks Paul; Tesfaye Binyam T.; Bickerstaff Matthew; Jackson Richard; Kanatas Anastios; Nixon Peter; McCaul James; Praveen Pray; Lowe Terry; Blanco-Guzman Manuel; Forner Lone; Brennan Peter; Fardy Mike; Parkin Richard; Smerdon Gary; Stephenson Ruth; Cope Tristan; Glover Mark

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HOPON (Hyperbaric Oxygen for the Prevention of Osteoradionecrosis): A Randomized Controlled Trial of Hyperbaric Oxygen to Prevent Osteoradionecrosis of the Irradiated Mandible After Dentoalveolar Surgery

机译：HOPON（用于预防骨质切割的高压氧气）：一种随机对照试验的高压氧试验，以防止牙眼镜术后辐照的颌下颌骨骨折

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Purpose: Hyperbaric oxygen (HBO) has been advocated in the prevention and treatment of osteoradionecrosis (ORN) of the jaw after head and neck radiation therapy, but supporting evidence is weak. The aim of this randomized trial was to establish the benefit of HBO in the prevention of ORN after high-risk surgical procedures to the irradiated mandible.

机译：目的：在头部和颈部放射治疗后的颌骨骨折（ORN）的预防和治疗中，已经提倡高压氧气（HBO），但是支持证据较弱。该随机试验的目的是在高风险外科手术到辐照下颌骨后建立HBO的益处。

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来源
《International Journal of Radiation Oncology, Biology, Physics》 |2019年第3期|共10页
作者
Shaw Richard J.; Butterworth Christopher J.; Silcocks Paul; Tesfaye Binyam T.; Bickerstaff Matthew; Jackson Richard; Kanatas Anastios; Nixon Peter; McCaul James; Praveen Pray; Lowe Terry; Blanco-Guzman Manuel; Forner Lone; Brennan Peter; Fardy Mike; Parkin Richard; Smerdon Gary; Stephenson Ruth; Cope Tristan; Glover Mark;
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作者单位

Univ Liverpool Liverpool Merseyside England;

Aintree Univ Hosp NHS Fdn Trust Dept Maxillofacial Surg Maxillofacial Prosthodont Liverpool;

Univ Liverpool Canc Res UK Liverpool Clin Trials Unit Liverpool Merseyside England;

Univ Liverpool Dept Mol &

Clin Canc Med Canc Res UK Liverpool Canc Trials Unit Liverpool;

Univ Liverpool Canc Res UK Liverpool Clin Trials Unit Liverpool Merseyside England;

Univ Liverpool Canc Res UK Liverpool Clin Trials Unit Liverpool Merseyside England;

Leeds Dent Inst OMFS Dept Leeds W Yorkshire England;

Leeds Dent Inst Restorat Dept Leeds W Yorkshire England;

Queen Elizabeth Univ Hosp Reg Maxillofacial Unit Glasgow Lanark Scotland;

Maxillofacial Off Queen Elizabeth Hosp Birmingham W Midlands England;

Aberdeen Royal Infirm Aberdeen Scotland;

Taunton &

Somerset NHS Fdn Trust Musgrove Pk Hosp Maxillofacial Unit Taunton Somerset England;

Copenhagen Univ Hosp Ctr Head &

Orthoped Dept Anesthesia Copenhagen Denmark;

Queen Alexandra Hosp Maxillofacial Unit Portsmouth Hants England;

Univ Hosp Wales Cardiff S Glam Wales;

ABUHB OMFS Dept Newport Gwent Wales;

DDRC Healthcare Hyperbar Med Ctr Plymouth Devon England;

Aberdeen Royal Infirm NHS Grampian Aberdeen Scotland;

Murrayfield Hosp North West Recompress Unit Holmwood England;

St Richards Hosp Hyperbar Med Unit Chichester England;

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正文语种 eng
中图分类放射医学;
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1. HOPON (Hyperbaric Oxygen for the Prevention of Osteoradionecrosis): A Randomized Controlled Trial of Hyperbaric Oxygen to Prevent Osteoradionecrosis of the Irradiated Mandible After Dentoalveolar Surgery [J] . Shaw Richard J., Butterworth Christopher J., Silcocks Paul, International Journal of Radiation Oncology, Biology, Physics . 2019,第3期

机译：HOPON（用于预防骨质切割的高压氧气）：一种随机对照试验的高压氧试验，以防止牙眼镜术后辐照的颌下颌骨骨折
2. Refining the definition of mandibular osteoradionecrosis in clinical trials: The cancer research UK HOPON trial (Hyperbaric Oxygen for the Prevention of Osteoradionecrosis) [J] . Shaw Richard, Tesfaye Binyam, Bickerstaff Matt, Oral oncology . 2017,第期

机译：精制临床试验中下颌骨骨切屑病的定义：癌症研究英国霍顿试验（预防骨质切屑的高压氧气）
3. Efficacy of pre- and postirradiation hyperbaric oxygen therapy in the prevention of postextraction osteoradionecrosis: a systematic review. [J] . Fritz GW, Gunsolley JC, Abubaker O, Journal of Oral and Maxillofacial Surgery . 2010,第11期

机译：辐照前和辐照后高压氧疗法在预防拔牙后骨放射性坏死中的功效：系统评价。
4. Hyperbaric Oxygen Therapy and Its Use in Neurology and Neurosurgery: Physiology and Applications with Examples [C] . Conference of the American College of Veterinary Internal Medicine (ACVIM) . 2017

机译：高压氧疗法及其在神经学和神经外科的应用：与实例的生理学和应用
5. The Effects of Hyperbaric Oxygen Therapy on Bone Distant From Sites of Surgery. [D] . Alghamdi, Mohammed Yousef Mohammed. 2011

机译：高压氧疗法对远离手术部位的骨的影响。
6. HOPON (Hyperbaric Oxygen for the Prevention of Osteoradionecrosis): a randomised controlled trial of hyperbaric oxygen to prevent osteoradionecrosis of the irradiated mandible: study protocol for a randomised controlled trial [O] . Richard Shaw, Christopher Butterworth, Binyam Tesfaye, 2018

机译：HOPON（高压氧用于预防骨放射性坏死）：高压氧预防照射下颌骨放射性坏死的随机对照试验：一项随机对照试验的研究方案
7. HOPON (Hyperbaric Oxygen for the Prevention of Osteoradionecrosis): A Randomized Controlled Trial of Hyperbaric Oxygen to Prevent Osteoradionecrosis of the Irradiated Mandible After Dentoalveolar Surgery [O] . Richard J. Shaw, Christopher J. Butterworth, Paul Silcocks, 2019

机译：HOPON（用于预防骨质切割的高压氧气）：一种随机对照试验的高压氧试验，以防止牙眼镜术后辐照的颌下颌骨骨折
8. Cognitive Function in a Traumatic Brain Injury Hyperbaric Oxygen Randomized Trial. [R] . Wolf, E. G., Baugh, L. M., Kabban, C. M., 2015

机译：创伤性脑损伤高压氧随机试验的认知功能。

HOPON (Hyperbaric Oxygen for the Prevention of Osteoradionecrosis): A Randomized Controlled Trial of Hyperbaric Oxygen to Prevent Osteoradionecrosis of the Irradiated Mandible After Dentoalveolar Surgery

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