In-vivo anti-diabetic and wound healing potential of chitosan/alginate/maltodextrin/pluronic-based mixed polymeric micelles: Curcumin therapeutic potential

摘要

Development of curcumin-loaded mixed polymeric micelles based on chitosan, alginate, maltodextrin, pluronic F127, pluronic P123, and tween 80, by thin-film hydration method has been investigated in Bisphenol A induced diabetics rats. Curcumin (C21H20O6) extracted from rhizomes of the "Curcuma longa" has attracted considerable attention of pharmaceutical researchers due to its low cost, excellent pharmacological activities and lesser side effects. Despite its diverse pharmacological properties, the therapeutic application of curcumin as an oral therapy has been limited due to its poor aqueous solubility, fixed chemical stability, and low bioavailability. In an attempt to overcome these limitations, we developed curcumin-loaded mixed polymeric micelles. Diabetes mellitus is a most common chronic carbohydrate metabolic disorder. The results clearly demonstrated the ability of developed formulation to reduce the elevated blood glucose level and lipid profile (total cholesterol, triglycerides). It maintained the body-weight, HDL cholesterol level, various biochemical parameters and accelerated the wound healing process when treated with these curcumin-based formulations. The treatment of curcumin loaded mixed polymeric formulations allowed a favorable inhibitory effect to these histopathological changes of liver, kidney, and pancreas. The newly developed curcumin-based formulations have proved superior therapeutic potential and excellent healing efficacy as compared to standard drugs and pure curcumin. (C) 2018 Elsevier B.V. All rights reserved .