Effect of Sonication on Certain Antiepileptic Drugs: Approach to Drug Delivery Mechanism Through Perfluorocarbon

摘要

Lennox-Gastaut type of seizures that affects the central nervous system(CNS)are facing drug administration problems.One such problem is that the delivery mechanism of antiepileptic drugs(AEDs)to the affected seizures is haunting the complete treatment of epilepsy.One of the better methods to overcome this problem is to attach the drug with a carrier agent and making it deliver at the proper site.In this paper,a novel attempt has been made to identify all possible attachment portions in the antiepileptic drugs like topiramate,carbamazepine and lamotrigine by sonicating(ultrasonic)the drugs at different timings and amplitudes.The disintegration of the drugs and the possible attachment points,for every different timing and amplitude,were analyzed through high performance liquid chromatography.An extensive study has been made on topiramate by reacting it with the chosen drug delivering agent perfluorodecalin(PFD)and subjected to sonication.The choice of perfluorodecalin is a novel intuition since they are traditionally used as oxygen carrier and blood substitute.The topiramate + perfluorodecalin emulsion is grown into a crystal.Complete structure has been elucidated through X-ray crystallographic studies.Results show that the sonication is one of the much easier and handy technique to break chemical bonds and to create cavitations thus allowing other molecules to occupy that space.Investigation further reveals that,more the number of nitrogen atoms,less they are interactive and less it responds to sonication effect.Hence we prefer to safely conclude that topiramate is more adaptive in the study of drug delivering mechanism though it possesses a bulk structure than lamotrigine and carbamazepine.