A Novel Method for Synthesis of Tetrahydro-2//-oxazolo[2,3-a]isoquinolines

摘要

An efficient and direct method for the synthesis of tetrahydro-2H-oxazolo[2,3-<2]isoquinolines is reported.This novel method involves ~RT3P mediated in situ oxidation of benzyl alcohols to aldehyde followed by acetic acid mediated [3+2] cycloaddition reaction to afford tetrahydro-2H-oxazolo[2,3-a]isoquinolines in one-pot operation with good to excellent yields.Heterocyclic alcohols also underwent the reaction with tetrahydroquinolines at room temperature.