A Green Synthesis,Molecular Docking and Cytotoxicity of(E)-1-(4-(Difluoromethoxy)-2-Hydroxybenzylidene)Semicarbazide

摘要

A green,one-pot three-components reaction of(E)-l-(4-(difluoromefhoxy)-2-hydroxybenzylidene)semicarbazide has been designed,synthesized and characterized by elemental,FT-IR,~1H and ~(l3)C NMR spectral data.The cytotoxic activities of the synthesized/compound were evaluated by MTT assay in human cancer cell lines.Docking studies of 3-substituted indolin-2-one scaffolds on vasculaf endothelial growth factor receptor 2(VEGFR-2)involved in cell proliferation and angiogenesis was performed.Based on the ligand efficiency indices,Scruff bases may be regarded as efficient candidates for further molecular developments of anticancer agents.The molecule is useful in sensing and drug-carrying applications.