Green Synthesis Approaches of 2-Bromo-4-methyI thiazole-5-carboxamide Derivatives as Potent Microbial Agents

摘要

As a part of our ongoing research in the development of new,selective and environmental friendly methodologies,herein we report a new series of 2-bromo-4-methylthiazole-5-carboxamide derivatives using polyethylene glycol-400(PEG-400)as a solvent.All the newly synthesized compounds were screened to their in vitro antimicrobial activities and all the compounds exhibited remarkable growth inhibition of wide spectrum of Gram-positive bacteria and Gram-negative bacteria.Molecular docking was done performed computational software GOLD(Genetic algorithm based,flexible ligand,partial flexibility for protein).