The influence of hydrodynamic diameter and core composition on the magnetoviscous effect of biocompatible ferrofluids

摘要

Suspensions of magnetic nanoparticles have received increasing interest in the biomedical field. While these ferrofluids are already used for magnetic resonance imaging, emerging research on cancer treatment focuses, for example, on employing the particles as drug carriers, or using them in magnetic hyperthermia to destroy diseased cells by heating of the particles. To enable safe and effective applications, an understanding of the flow behaviour of the ferrofluids is essential. Regarding the applications mentioned above, in which flow phenomena play an important role, viscosity under the influence of an external magnetic field is of special interest. In this respect, the magnetoviscous effect (MVE) leading to an increasing viscosity if an external magnetic field of a certain strength is applied, is well-known for singlecore ferrofluids used in the engineering context. In the biomedical context, multicore ferrofluids are preferred in order to avoid remanence magnetization and to enable a deposition of the particles by the organism without complications. This study focuses on a comparison of the MVE for three ferrofluids whose composition is identical except in relation to their hydrodynamic diameter and core composition-one of the fluids contains singlecore particles, while the other two feature multicore particles. This enables confident conclusions about the influence of those parameters on flow behaviour under the influence of a magnetic field. The strong effects found for two of the fluids should be taken into account, both in future investigations and in the potential use of such ferrofluids, as well as in manufacturing, in relation to the optimization of flow behaviour.