Dorsal Hippocampal-Dependent Episodic Memory Inhibits Eating

摘要

Research regarding how the brain regulates eating behavior has focused largely on homeostatic (i.e., need-based) and hedonic (i.e., pleasure-based) controls. By contrast, there is a large gap in our understanding of how brain areas involved in cognitive processes, such as memory, impact energy intake. Moreover, compared to meal size and satiety, little is known about how the brain controls meal timing and frequency. My research team and I hypothesize that dorsal hippocampal neurons, which are critical for episodic memory of personal experiences, form a memory of a meal, inhibit meal initiation during the period following that meal, and limit the amount ingested at the next meal. I review evidence supporting this hypothesis and raise the possibility that impaired dorsal hippocampal function contributes to diet-induced obesity.