Design, Synthesis, Antifungal, and Antioxidant Activities of (E)-6-((2-Phenylhydrazono)methyl)quinoxaline Derivatives

摘要

Different substituted phenylhydrazone groups were linked to the quinoxaline scaffold to provide 26 compounds (6a—6z). Their structures were confirmed by ~1H and ~(13)C NMR, MS, elemental analysis, and X-ray single-crystal diffraction; The antifungal activities of these compounds against Rhizoctonia solani were evaluated in vitro. Compound 6p is the most promising one among all the tested compounds with an EC_(50) of 0.16 μg·mL~(-1), more potent than the coassayed positive control fungicide carbendazim (EC_(50): 1.42, μg·mL~(-1)). In addition, these compounds were subjected to antioxidant assay by employing diphenylpicrylhydrazyl (DPPH) and mice microsome lipid peroxidation (LPO) methods.