Intestinal Absorption and Blood Clearance of L-Histidine-Related Compounds after Ingestion of Anserine in Humans and Comparison to Anserine-Containing Diets

摘要

Anserine is a bioactive dipeptide found in muscles and brains of vertebrates,but little is known about the kinetics of its absorption into blood and the clearance after the ingestion of anserine or anserine-containing diets.This study investigated time-dependent changes in the concentrations of L-histidine-related compounds from deproteinized blood.The concentration of anserine peaked and then decreased to zero,whereas the concentration of pi-methylhistidine gradually increased,at which point anserine was not detected.Thus,ingested anserine is absorbed intact in human blood and is hydrolyzed to pi-methylhistidine and beta-alanine by serum and tissue carnosinases.Moreover,the crossover study suggests that there was no significant difference in absorption under curves of anserine between anserine alone and anserine-containing diet,whereas there was significant difference in the peak concentration of anserine.This is the first study to demonstrate intestinal absorption and blood clearance of anserine.