Effect of Chemoradiotherapy vs Chemotherapy on Survival in Patients With Locally Advanced Pancreatic Cancer Controlled After 4 Months of Gemcitabine With or Without Erlotinib The LAP07 Randomized Clinical Trial

Hammel Pascal; Huguet Florence; van Laethem Jean-Luc; Goldstein David; Glimelius Bengt; Artru Pascal; Borbath Ivan; Bouche Olivier; Shannon Jenny; Andre Thierry; Mineur Laurent; Chibaudel Benoist; Bonnetain Franck; Louvet Christophe

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Effect of Chemoradiotherapy vs Chemotherapy on Survival in Patients With Locally Advanced Pancreatic Cancer Controlled After 4 Months of Gemcitabine With or Without Erlotinib The LAP07 Randomized Clinical Trial

机译：放化疗与化学疗法对吉西他滨4个月合并或不合并厄洛替尼的局部晚期胰腺癌患者生存率的影响LAP07随机临床试验

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IMPORTANCE In locally advanced pancreatic cancer, the role of chemoradiotherapy is controversial and the efficacy of erlotinib is unknown.

机译：重要在局部晚期胰腺癌中，放化疗的作用尚存争议，厄洛替尼的疗效尚不清楚。

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《JAMA: the Journal of the American Medical Association》 |2016年第17期|共10页
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Hammel Pascal; Huguet Florence; van Laethem Jean-Luc; Goldstein David; Glimelius Bengt; Artru Pascal; Borbath Ivan; Bouche Olivier; Shannon Jenny; Andre Thierry; Mineur Laurent; Chibaudel Benoist; Bonnetain Franck; Louvet Christophe;
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1. Effect of Chemoradiotherapy vs Chemotherapy on Survival in Patients With Locally Advanced Pancreatic Cancer Controlled After 4 Months of Gemcitabine With or Without Erlotinib The LAP07 Randomized Clinical Trial [J] . Hammel Pascal, Huguet Florence, van Laethem Jean-Luc, JAMA: the Journal of the American Medical Association . 2016,第17期

机译：放化疗与化学疗法对吉西他滨4个月合并或不合并厄洛替尼的局部晚期胰腺癌患者生存率的影响LAP07随机临床试验
2. Gemcitabine and S-1 combination chemotherapy versus gemcitabine alone for locally advanced and metastatic pancreatic cancer: a meta-analysis of randomized controlled trials in Asia [J] . Li Yanxun, Sun Jinjin, Jiang Zhijia, Journal of chemotherapy . 2015,第4期

机译：吉西他滨和S-1联合化疗与单独使用吉西他滨治疗局部晚期和转移性胰腺癌：亚洲随机对照试验的荟萃分析
3. Phase II clinical trial of induction chemotherapy with fixed dose rate gemcitabine and cisplatin followed by concurrent chemoradiotherapy with capecitabine for locally advanced pancreatic cancer [J] . KimJ.-S., LimJ.H., KimJ.H., Cancer chemotherapy and pharmacology. . 2012,第3期

机译：固定剂量率吉西他滨和顺铂诱导化疗联合卡培他滨联合放化疗治疗局部晚期胰腺癌的II期临床试验
4. Brain cortical structural differences between non-central nervous system cancer patients treated with and without chemotherapy compared to non-cancer controls: a cross-sectional pilot MRI study using clinically-indicated scans [C] . Mark S. Shiroishi, Vikash Gupta, Bavrina Bigjahan, 13th international conference on medical information processing and analysis . 2017

机译：与非癌症对照组相比，接受和不接受化疗的非中枢神经系统癌症患者的大脑皮层结构差异：采用临床指征扫描的横断面MRI研究
5. Results of a randomized, controlled trial to assess the toxicity and patient adherence with two short-course regimens for the prevention of tuberculosis, a two-month regimen of rifampin and pyrazinamide or a four-month regimen of rifampin only, in comparison with a control regimen of six-months-isoniazid. [D] . Geiter, Lawrence James. 1997

机译：与对照相比，采用两种短期疗程预防结核病，两个月利福平和吡嗪酰胺治疗或仅四个月利福平治疗，评估毒性和患者依从性的随机对照试验结果六个月异烟肼的治疗方案。
6. Chemoradiotherapy with concurrent gemcitabine and cisplatin with or without sequential chemotherapy with gemcitabine/cisplatin vs chemoradiotherapy with concurrent 5-fluorouracil in patients with locally advanced pancreatic cancer – a multi-centre randomised phase II study [O] . R Wilkowski, S Boeck, S Ostermaier, 2009

机译：局部晚期胰腺癌患者中同时进行吉西他滨和顺铂联合放化疗或不联合进行吉西他滨/顺铂化疗与同期5-氟尿嘧啶放化疗联合5-氟尿嘧啶治疗
7. Chemoradiotherapy with concurrent gemcitabine and cisplatin with or without sequential chemotherapy with gemcitabine/cisplatin vs chemoradiotherapy with concurrent 5-fluorouracil in patients with locally advanced pancreatic cancer – a multi-centre randomised phase II study [O] . Wilkowski, R, Boeck, S, Ostermaier, S, 2009

机译：局部晚期胰腺癌患者中同时吉西他滨和顺铂联合或不联合吉西他滨/顺铂联合化学放化疗与5-氟尿嘧啶同时化疗的放化疗–多中心随机II期研究

Effect of Chemoradiotherapy vs Chemotherapy on Survival in Patients With Locally Advanced Pancreatic Cancer Controlled After 4 Months of Gemcitabine With or Without Erlotinib The LAP07 Randomized Clinical Trial

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