National and multinational prospective trial registers.

摘要

Clinical trials are an essential source of scientific evidence on the safety and effectiveness of health interventions. Prospectively registering information about atrial before enrolling participants, tracking changes to that information via a publicly accessible audit trail, and reporting results on completion of the trial helps protect against reporting biases and over-optimistic conclusions about treatment benefits. Open-access registries should decrease wasteful duplication of research, promote more efficient allocation of research funds, and ensure trial information is disseminated and incorporated into the appropriate body of evidence for clinical, funding, and ethical decision-making.