Organocatalytic Enantioselective Direct Vinylogous Michael Addition of alpha,beta-Unsaturated gamma-Butyrolactam to beta-Acyl Acrylates and 1,2-Diacylethylenes

Chen Yi-Ru; Das Utpal; Liu Meng-Hsien; Lin Wenwei

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Organocatalytic Enantioselective Direct Vinylogous Michael Addition of alpha,beta-Unsaturated gamma-Butyrolactam to beta-Acyl Acrylates and 1,2-Diacylethylenes

机译：α，β-不饱和γ-丁内酰胺的有机催化对映选择性直接乙烯基加成到β-丙烯酸丙烯酸酯和1,2-二酰基乙烯

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A highly efficient Michael addition of alpha,beta-unsaturated gamma-butyrolactam to various beta-acyl acrylates and ene-diones to provide synthetically useful compounds was developed. The products were obtained with high diastereo- and enantioselectivities (up to >25:1 dr and 99% ee) containing adjacent tertiary stereocenters.

机译：开发了一种高效的迈克尔加成α，β-不饱和的γ-丁内酰胺到各种β-丙烯酸丙烯酸酯和烯-二酮中以提供合成上有用的化合物。获得的产物具有高非对映选择性和对映选择性（高达> 25：1 dr和99％ee），并包含相邻的叔立体中心。

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《The Journal of Organic Chemistry》 |2015年第3期|共8页
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Chen Yi-Ru; Das Utpal; Liu Meng-Hsien; Lin Wenwei;
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1. Organocatalytic Enantioselective Direct Vinylogous Michael Addition of alpha,beta-Unsaturated gamma-Butyrolactam to beta-Acyl Acrylates and 1,2-Diacylethylenes [J] . Chen Yi-Ru, Das Utpal, Liu Meng-Hsien, The Journal of Organic Chemistry . 2015,第3期

机译：α，β-不饱和γ-丁内酰胺的有机催化对映选择性直接乙烯基加成到β-丙烯酸丙烯酸酯和1,2-二酰基乙烯
2. Organocatalytic enantioselective direct vinylogous michael addition of γ-substituted butenolides to 3-aroyl acrylates and 1,2-diaroylethylenes [J] . Das U., Chen Y.-R., Tsai Y.-L., Chemistry: A European journal . 2013,第24期

机译：γ-取代的丁烯内酯的有机催化对映选择性直接乙烯基迈克尔加成到丙烯酸3-芳酰基酯和1,2-二戊酰基乙烯
3. Direct Catalytic Asymmetric Doubly Vinylogous Michael Addition of alpha,beta-Unsaturated gamma-Butyrolactams to Dienones [J] . Gu Xiaodong, Guo Tingting, Dai Yuanyuan, Angewandte Chemie . 2015,第35期

机译：α，β-不饱和γ-丁内酰胺的直接催化不对称双酿酒迈克尔加成到二烯
4. Enantioselective Organocatalytic Michael Addition of Aldehydes to β-Nitrostyrenes [C] . Marju Laars, Kerti Ausmees, Tonis Kanger European Symposium on Organic Chemistry . 2009

机译：对β-硝化丁烯的映选择性有机催化迈克尔添加醛
5. Part I. Asymmetric organocatalysis: (1) Direct enantioselective organocatalytic hydroxymethylation of aldehydes catalyzed by alpha,alpha-diphenylprolinol trimethylsilyl ether: Application in the formal synthesis of (-)-Rasfonin; (2) Synthesis of a novel bicyclic secondary amine organocatalyst: Application to the direct enantioselective organocatalytic hydroxymethylation of aldehydes. Part II. Asymmetric synthesis of bicyclic analogues of the anti-osteoporotic drug risedronate. [D] . Miller, John Robert. 2010

机译：第一部分，不对称有机催化：（1）α，α-二苯基脯氨醇三甲基甲硅烷基醚催化的醛的直接对映选择性有机催化羟甲基化：在（-）-Rasfonin的正式合成中的应用；（2）新型双环仲胺有机催化剂的合成：应用于醛的直接对映选择性有机催化羟甲基化。第二部分抗骨质疏松药物Risedronate的双环类似物的不对称合成。
6. Organocatalytic tandem Michael addition reactions: A powerful access to the enantioselective synthesis of functionalized chromenes thiochromenes and 12-dihydroquinolines [O] . Chittaranjan Bhanja, Satyaban Jena, Sabita Nayak, 2012

机译：有机催化串联迈克尔加成反应：功能化二苯甲基硫代二苯甲基和12-二氢喹啉对映选择性合成的强大途径
7. Enantioselective, Organocatalytic, Dissymmetric 1,4- and 1,2-Addition of Malononitrile to a Keto-bisenone Followed by an Oxa-Michael Addition Cascade [O] . -1

机译：对Keto-Bisenone的映选择性，有机催化，不对称的1,4-和1,2-加入丙二腈，然后加入牛肉 - 迈克尔加成级联

Organocatalytic Enantioselective Direct Vinylogous Michael Addition of alpha,beta-Unsaturated gamma-Butyrolactam to beta-Acyl Acrylates and 1,2-Diacylethylenes

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