Chiral carbene approach to gold-catalyzed asymmetric cyclization of 1,6-enynes

摘要

Chiral C2-symmetric N-heterocyclic carbenes (NHCs) were tested for their stereocontrolling abilities in gold(I)-catalyzed asymmetric cyclization of 1,6-enynes giving the corresponding cyclopentane derivatives with moderate enantioselectivity of up to 59%.