Synthetic studies toward tricyclic cembranoids:a modular approach for the construction of the tricyclic framework of eunicin

摘要

The synthesis of a sugar derived allene and its intramolecular silver mediated etherification followed by ring closing metathesis has been explored for building the tricyclic framework of eunicin.Cembranoids belong to a class of diterpenoids possessing a 14-membered ring.Cembrane A (Fig.1) compounds form the basic skeleton of these macrocyclic diterpenoids.Numerous cembranoids have been isolated from corals and other marine sources as well as from tobacco and other plants.