A simpler and greener protocol for the preparation of beta-acetylamino ketones by a one-pot reaction of aryl aldehydes,enolisable ketones,acetyl chloride and acetonitrile in the presence of zeolite Hp as a reusable catalyst

摘要

P-Acetylamino ketones have been obtained in a one-pot coupling of an aldehyde with an enolisable ketone,acetyl chloride and acetonitrile in the presence of zeolite HP as catalyst at room temperature (26-28 deg C).The procedure has the advantages of mild workup,circumvention of high temperature and inert atmosphere.The catalyst was found to be recyclable.