A facile synthesis of Cerny epoxides and selectively blocked derivatives of 2-azido-2-deoxy-#beta#-D-glucopyranose

摘要

1,6:2,3-Dianhydro-#beta#-D-glucopyranose and its 3-alkylated derivatives were prepared from D-glucal in one pot with overall isolated yields of 60-70%, and these Cerny epoxides were further conveniently converted to selectively blocked 2-azido-2-deoxy-#beta#-D-glucopyranose derivatives by azido opening of the epoxide ring.