Practical synthesis of 1,5-dimethyl substituted conjugated polyenes from geranyl acetate

摘要

A protocol to synthesize 1,5-dimethyl substituted conjugated polyenes via dehydrogenation of geranyl acetate was established. C-5 unit elongation to multi- 1,5-dimethyl substituted conjugated polyenes was also achieved via Horner-Wadsworth-Emmons olefination in good yields and good selectivities. (C) 2008 Elsevier Ltd. All rights reserved.