Highly chemoselective hydrogenation method using novel finely dispersed palladium catalyst on silk-fibroin: its preparation and activity

摘要

A palladium-fibroin complex (Pd/Fib) was prepared by soaking silk-fibroin in MeOH solution of Pd(OAc)(2) for 2 days (under Ar atmosphere)-4 days (under air). Pd(OAc)(2) was gradually absorbed by fibroin and the rapid reduction of fibroin conjugated Pd(OAc)(2) proceeded with MeOH as a reductant at room temperature to be the Pd(0) complex. Pd/Fib catalyzed chemoselective hydrogenation of acetylenes, olefins and azides in the presence of aromatic ketones and aldehydes, halides, N-Cbz protective groups and benzyl esters which are readily hydrogenated using Pd/C or Pd/C(en) as a catalyst. (C) 2004 Elsevier Ltd. All rights reserved.