Palladium-catalyzed homocouplingr of aryl halides in the presence of fluoride

摘要

This report describes the fluoride-mediated homocoupling of aryl iodides and bromides catalyzed by palladium(0). This coupling protocol is tolerant of electron-donating and electron-withdrawing substitutents on the aryl halide, as well as ortho substitution. Optimum reaction conditions entail 10 mol% Pd(dba)(2), 3 equiv of tetrabutyl ammonium fluoride (TBAF) in DMF at 90 degreesC. (C) 2004 Elsevier Ltd. All rights reserved.