PURPOSE: To evaluate the histopathological features of corneal graft failures over time. METHODS: A single-center retrospective analysis was performed on corneal specimens diagnosed as corneal graft failure retrieved from The Henry C. Witelson Ophthalmic Pathology Laboratory and Registry (Montreal, Canada) over a 9-year period. The corneal buttons were divided into 3 different groups according to the time between the diagnosis of corneal graft failure and regraft. Corneal specimens obtained during keratoplasty were subjected to hematoxylin and eosin and periodic acid-Schiff. Five different histopathological findings were evaluated in each specimen. RESULTS: Overall, the most common histopathological finding was endothelial decompensation (97.2%). Subepithelial pannus (38.9%), vessels in the corneal stroma (11.1%), and anterior synechiae (2.8%) were the other present findings. The inflammatory reaction was considered discrete in 83.3% of the cases. The only significant histopathological finding correlated with time was the presence of vessels in the corneal stroma (P = 0.0092). CONCLUSIONS: Corneal neovascularization, represented by the presence of vessels in the corneal stroma, was the only histopathological finding correlated with time. Because it is a known factor of poor prognosis, our findings strongly support that early regraft has higher chances of success.
展开▼
机译：目的：评估随时间推移的角膜移植失败的组织病理学特征。方法：在9年的时间里，对从Henry C. Witelson眼科病理实验室和注册处（加拿大蒙特利尔）取回的被诊断为角膜移植失败的角膜标本进行了单中心回顾性分析。根据角膜移植物的诊断与再植之间的时间，将角膜钮扣分为3个不同的组。对角膜移植过程中获得的角膜标本进行苏木精，曙红和高碘酸席夫氏治疗。在每个标本中评估了五种不同的组织病理学发现。结果：总体而言，最常见的组织病理学发现是内皮失代偿（97.2％）。上皮下血管findings（38.9％），角膜基质中的血管（11.1％）和前粘连（2.8％）是目前的其他发现。在83.3％的病例中，炎症反应被认为是离散的。唯一与时间相关的重要组织病理学发现是角膜基质中存在血管（P = 0.0092）。结论：以角膜基质中血管的存在为代表的角膜新生血管形成是唯一与时间相关的组织病理学发现。因为这是预后不良的已知因素，所以我们的发现强烈支持早期移植物成功的可能性更高。
展开▼
