Diastereoselective intramolecular friedel-crafts cyclizations of substituted methyl 2-(1 H-indole-1-carbonyl)acrylates: Efficient access to functionalized 1 H-pyrrolo[1,2-a]indoles

摘要

A general, catalytic method for the diastereoselective synthesis of functionalized 1H-pyrrolo[1,2-a]indoles via an intramolecular Friedel-Crafts alkylation of N-acyl indoles is reported. Products were obtained in excellent yields (up to 98%) with high diastereoselectivities (up to >25:1 dr).