Synthesis of Diazacalix[8]arene and Triazacalix[12]arene Methyl Ethers via Intramolecular Aryl Amination

摘要

Azacalixarenes derived from p-tert-butylphenol are generated by an intramolecular aryl amination strategy as the ring-closing step. The reaction produces the first examples of larger p-tert-butylcalixarenes with regioselective substitution of bridging methylenes with nitrogen atoms.