Organocatalytic Michael Addition of Aldehydes to Vinyl Sulfones: Enantioselective alpha-Alkylations of Aldehydes and Their Derivatives

Zhu Q; Lu YX

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Organocatalytic Michael Addition of Aldehydes to Vinyl Sulfones: Enantioselective alpha-Alkylations of Aldehydes and Their Derivatives

机译：醛与乙烯基砜的有机催化迈克尔加成反应：醛及其衍生物的对映选择性α-烷基化反应

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Organocatalytic asymmetric Michael reaction of unmodified aldehydes to vinyl sulfones catalyzed by silylated biarylprolinol afforded the desired Michael products with exceptional enantioselectivity. The described enantioselective addition to vinyl sulfones, in combination with desulfonation, offers a unique, asymmetric entry to alpha-alkylated aldehydes and their derivatives.

机译：甲硅烷基化的联芳基脯氨醇催化的未修饰醛与乙烯基砜的有机催化不对称迈克尔反应提供了所需的迈克尔产物，且具有出色的对映选择性。所描述的乙烯基砜的对映选择性加成与脱硫结合提供了α-烷基化醛及其衍生物的独特，不对称入口。

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《Organic letters》 |2008年第21期|共4页
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Zhu Q; Lu YX;
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机译：敌人;以太;

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1. Organocatalytic Michael Addition of Aldehydes to Vinyl Sulfones: Enantioselective alpha-Alkylations of Aldehydes and Their Derivatives [J] . Zhu Q, Lu YX Organic letters . 2008,第21期

机译：醛与乙烯基砜的有机催化迈克尔加成反应：醛及其衍生物的对映选择性α-烷基化反应
2. A new class of structurally rigid tricyclic chiral secondary amine organocatalyst: Highly enantioselective organocatalytic Michael Addition of aldehydes to vinyl sulfones [J] . Xiao J., Lu Y.-P., Liu Y.-L., Organic letters . 2011,第5期

机译：一类新的结构刚性的三环手性仲胺有机催化剂：高度对映选择性的有机迈克尔催化醛与乙烯基砜的加成反应
3. A new class of structurally rigid tricyclic chiral secondary amine organocatalyst: Highly enantioselective organocatalytic Michael Addition of aldehydes to vinyl sulfones [J] . Xiao J., Lu Y.-P., Liu Y.-L., Organic letters . 2011,第5期

机译：一类新的结构刚性的三环手性仲胺有机催化剂：高度对映选择性的有机迈克尔催化醛与乙烯基砜的加成反应
4. Enantioselective Organocatalytic Michael Addition of Aldehydes to β-Nitrostyrenes [C] . Marju Laars, Kerti Ausmees, Tonis Kanger European Symposium on Organic Chemistry . 2009

机译：对β-硝化丁烯的映选择性有机催化迈克尔添加醛
5. Part I. Asymmetric organocatalysis: (1) Direct enantioselective organocatalytic hydroxymethylation of aldehydes catalyzed by alpha,alpha-diphenylprolinol trimethylsilyl ether: Application in the formal synthesis of (-)-Rasfonin; (2) Synthesis of a novel bicyclic secondary amine organocatalyst: Application to the direct enantioselective organocatalytic hydroxymethylation of aldehydes. Part II. Asymmetric synthesis of bicyclic analogues of the anti-osteoporotic drug risedronate. [D] . Miller, John Robert. 2010

机译：第一部分，不对称有机催化：（1）α，α-二苯基脯氨醇三甲基甲硅烷基醚催化的醛的直接对映选择性有机催化羟甲基化：在（-）-Rasfonin的正式合成中的应用；（2）新型双环仲胺有机催化剂的合成：应用于醛的直接对映选择性有机催化羟甲基化。第二部分抗骨质疏松药物Risedronate的双环类似物的不对称合成。
6. Enantioselective Organocatalytic Michael Addition of Aldehydes to Nitroethylene: Efficient Access to γ2-Amino Acids [O] . Yonggui Chi, Li Guo, Nathan A. Kopf, -1

机译：醛对硝基乙烯的对映选择性有机催化迈克尔加成反应：高效地获得γ2-氨基酸
7. A New Class of Structurally Rigid Tricyclic Chiral Secondary Amine Organocatalyst:Highly Enantioselective Organocatalytic Michael Addition of Aldehydes to Vinyl Sulfones [O] . 肖建, YunPengLu, YanLingLiu, 2011

机译：a New Class of structurally Rigid Tricyclic Chiral secondary amine Organocatalyst:Highly Enantioselective Organocatalytic michael addition of aldehydes to Vinyl sulfones
8. Chiral Oxazaborolidines as Catalysts for the Enantioselective Addition of Diethylzinc to Aldehydes [R] . Joshi, N. N., Srebnik, M., Brown, H. C. 1989

机译：手性恶唑硼烷作为二乙基锌对醛的不对称加成催化剂

Organocatalytic Michael Addition of Aldehydes to Vinyl Sulfones: Enantioselective alpha-Alkylations of Aldehydes and Their Derivatives

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