Semiparametric Box-Cox power transformation models for censored survival observations

摘要

The accelerated failure time model specifies that the logarithm of the failure time is linearly related to the covariate vector without assuming a parametric error distribution. In this paper, we consider the semiparametric Box-Cox transformation model, which includes the above regression model as a special case, to analyse possibly censored failure time observations. Inference procedures for the transformation and regression parameters are proposed via a resampling technique. Prediction of the survival function of future subjects with a specific covariate vector is also provided via pointwise and simultaneous interval estimates. All the proposals are illustrated with datasets from two clinical studies.