Synthesis, characterization, structural study and antibacterial activity of the Schiff bases derived from sulfanilamides and related copper(II) complexes

摘要

In the present work, a series of new Schiff base ligands from acetylacetone and salicylaldehyde with sulfonamides derivatives were synthesized and characterized by spectral and analytical techniques. The molecular structures of ligands, N-({4-[(E)-(2-hydmxybenzylidene}aminolphenyl)sulfonyle)acetamide (HL1), N-({4-[(E)-(2-hydroxybenxiliden)aminolphenyl}sulfonyle)benzamide (HL2) and 4-((4-oxopentan-2ylidene)amino)benzenesulfonamide (HL3) were also determined by the method of X-ray diffraction. Also, new copper(II) complexes [CuLx](x = 1 for 1, x= 2 for 2, x= 3 for 3) constructed from HLx were synthesized and characterized by FT-IR, UV-vis spectroscopy and XRD. The copper(II) complexes were screened for their antimicrobial activities against the selected bacteria and compared to the free ligands, using the disc diffusion method. (C) 2016 Elsevier B.V. All rights reserved.