Synthesis and Antimicrobial Activities of 2,5-Substituent Hydroquinone Derivatives

摘要

A series of 2,5-substituent hydroquinone derivatives were designed and synthesized. Their structures were identified by elemental analysis, ~1H NMR, IR spectra. Their assayed antibacterial (Escherichia coli. Bacillus subtilis) and antifungal (Candida albicans) activities were also evaluated by MTT (3-(4.5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) method. The results of biological test showed compounds 1 and 10 have favorable antimicrobial activity with MICs of 20.5. 24.6, 18.9 and 28.6 μg/mL against Escherichia coli and Bacillus subtilis, respectively.