TFA-Mediated Alkyne Hydration Reaction to Synthesize Methyl Ketones

摘要

Trifluoroacetic acid efficiently promotes the hydration of terminal alkynes without the use of other catalysts to afford a wide variety of methyl ketones in good to excellent yields with perfect regioselectivities. This new procedure offers significant advantages over previous synthetic approaches, including brevity, mild reaction conditions, excellent yields and high functional group tolerance.