Positron Emission Tomography Imaging of Drug-Induced Tumor Apoptosis with a Caspase-Triggered Nanoaggregation Probe

摘要

Positron emission tomography (PET) is a powerful noninvasive molecular imaging technique that uses molecules labeled with positron-emitting isotopes such as carbon-11, fluorine-18, and copper-64, to monitor biochemical processes in living subject in real time with excellent sensitivity. A contrast-enhanced PET image is produced through selective retention of radioactivity at the location where the molecular target is present, and the common strategy is based on the binding of a radiolabeled ligand to the target receptor molecule.