Practical One-Pot Preparation of Magnesium Di(hetero)aryl- and Magnesium Dialkenylboronates for Suzuki-Miyaura Cross-Coupling Reactions

摘要

Arylboron derivatives have found broad applications in Suzuki-Miyaura cross-coupling reactions. In particular, various boronic acids, esters, and their derivatives, such as trifluoroborates, MIDA boronates or DAN reagents, have been used very successfully (MIDA = N-methyliminodi-acetic acid, DAN = 2,3-diaminonaphthalene). In general, most arylboronic compounds are prepared via lithium or magnesium organometallic compounds in a two-step process, although direct transition-metal-catalyzed borylations can also be realized. Furthermore, a one-pot preparation of arylboronic esters by using an iodine/magnesium exchange has been reported.