Development of Transdermal Drug Delivery System of Tulobuterol for Asthma Theatment Based on Chronotherapy

摘要

It is well known that vulnerable period exists in the manifestation of asthma with maximum incidence of asthma attacks in early monring at around 4 a.m.due to morning dip in circadian rhythm.Oral dosage forms of beta_2-adrenergic agonists have been widely used to treat asthma patients.But they cannot cover the time of morning dip,and side effects such as palpitation and tremor caused by of excessive serum levels around Tmax limit their usefulness.Chronotherapy for asthma treamtnet based on circadian rhythm was considere dthat it would be more efficient and had a lower frequency of side effects.Accordingly we developed a novel transdermal drug delivery system of the beta_2-agonist tulobuterol adapted to the circadian rhythm.