Pyridylsilyl Group as a Multifunctional Phase Tag for Solution-Phase Synthesis

摘要

A novel phase tag strategy for the solution-phase synthesis, in which a 2-pyridyldimethylsilyl group functions as an efficient tag for acid/base extraction, is described. Various tagging and detagging protocols, and transformations using building blocks bearing the 2-pyridyldimethylsilyl group have been developed.