Eosinophilic pustular folliculitis successfully treated with sequential therapy of interferon-gamma and ciclosporin.

摘要

Eosinophilic pustular folliculitis (EPF), first described by Ofuji et al. in 1970, is a rare dermatosis of unknown aetiology, but a Th2 cytokine-disordered mechanism has been postulated. This disease is characterized clinically by pruritic follicular papulopustules associated with massive infiltration of eosinophils into the follicles and sebaceous glands and by blood eosinophilia.2 Because eosinophil growth and differentiation is specifically supported by interleukin (IL)-5 in vitro,3 inhibition of IL-5 production may lead to the therapeutic effectiveness in EPF. We report a patient with EPF successfully treated with systemic interferon (D?N)-y followed by ciclosporin administration.