From steroid hormones to depressive states and senile dementias: New mechanistic, therapeutical and predictive approaches

摘要

The discovery of "neurosteroids" leads to new descriptions and treatments of neuropathological pathologies. 3-beta-methoxy-pregnenolone may be used to treat alterations of neuro-traumatisms and cerebral lesions associated with depressive states. Protein FKBP52 is involved in the dysfunction of the tau protein in Alzheimer's disease and senile dementias. In all cases, neuronal microtubules are involved in the mechanism of lesions and their repair. (C) 2015 Published by Elsevier Masson SAS on behalf of Academie des sciences.