The influence of apolipoprotein A5 T-1131C and apolipoprotein E common genetic variants on the levels of hemostatic markers in dyslipidemic patients

摘要

Objectives: The aim of this study was to evaluate the relationships of the T-1131C (rs662799) polymorphism variants of apolipoprotein A5 (Apo A5) gene and variants of apolipoprotein E (Apo E) gene common polymorphism (rs429358, rs7412) to selected hemostatic markers.Study design and methods: We examined 590 asymptomatic dyslipidemic patients, subsequently divided into MetS+ (n = 146) and MetS- (n = 444) groups according to the criteria for identification of the metabolic syndrome (MetS). We compared variant frequencies and differences in levels of hemostatic markers according to Apo A5, Apo E and Apo A5/Apo E common variants.Results: The -1131C Apo A5 minor variant was associated with elevated tissue plasminogen activator (tPA) in comparison to TT genotype (p < 0.001), but not in the MetS + group. The analysis of Apo A5/Apo E common variants in all subjects revealed that the presence of - 1131C minor allele has always been associated with higher levels of tPA in comparison with T allele, regardless of Apo E genotype. Also the presence of minor Apo E2 allele led to elevated tPA concentrations in both T and C carriers. In addition, common - 1131C/E2 variant was associated with the highest tPA levels.Conclusion: We demonstrated a remarkable association especially between the - 1131C Apo A5 variant and increased tPA levels in asymptomatic dyslipidemic patients.