Composition of proteoglycans in mouse hepatoma cell nuclei

摘要

It was shown, that in process of transformation to the active proliferation state the change of the PG (GAG) composition' in the cell nuclei took place. Hepaxan sulfate proteoglycan (HSPG), dermatan sulfate proteoglycan (DSPG) and chondroitin sulfate proteoglycan (CSAC PG) were identified in the mouse hepatoma cell nuclei, whereas CSAC PG is absent in the normal mouse liver cell nuclei. The main component of nuclear PG carbohydrate chains of the tumor cells was shown to be heparan sulfate (HS), whereas dermatan sulfate (DS) is the main carbohydrate component of the normal cell nuclei.