Preparation Fundamental Characteristics and Biosafety Evalution of Compound rhBMP-2/CPC

摘要

To study the fundamental characteristics and biosafety of the compound bone morphogenetic protein ( BMP) and rhBMP- 2/CPC, and to provide a theoretical basis for the compound biologically active artificial bone mack of calcium phosphate cement ( CPC) and bone morphogenetic protein, simplex CPC was taken as the control group, and the compound with the blending ratio of 1g CPC to 5 mg rhBMP- 2 was taken as the experi-mentation group to determine the setting time , compressive strength , acute toxicological and sub acute toxicological properties. The osteogenic characteristic of compound rhBMP- 2/ CPC was measured by making animal model of radio discontinuous defect. The setting time of the two groups meets the clinical requirements , and the compressive strength of the solidified body of bone cement increases along with increasing the immersion time . Compound rhBMP-2/ CPC has a favorable osteogenic characteristic for animal model of radio discontijiuous defect. The fundamental characteristics of the compound rhBMP- 2 phosphate bone cement are basically the same as that of CPC, and also have a favorable biosafety and osteogenesis .