We present the first case of an endolaryngeal manifestation of a myxofibrosarcoma. These tumors represent a distinct clinicopathologic entity and are fibroblast-derived soft-tissue neoplasms usually arising in late adulthood. The tumor presented as an edematous swelling of the right vocal fold, appearing as a common Reinke edema. Surgery is the most common form of therapy, only a limited number of papers dealing with radio/chemotherapy exist due to the small number of cases. Unilateral cordectomy was performed, tumor was resected with negative surgical margins. This is the first report of an endolaryngeal myxofibrosarcoma. The tumor presented clinically as a unilateral swelling of the right vocal fold.
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