Voltammetric study and electrode kinetics of[Mn-sulfonamide-cephazolin]system at dropping mercury electrode

摘要

Stability constants(log P)of ternary complex of Mn~(II)with sulfadiazine,sulfisoxazole,sulfamethaxyzole,sulfamethazine,sulfathiazole,sulfacetamide and sulfanilamide as primary ligands and cephazolin as secondary ligands were reported at pH=7.30±0.01 at mu=1.0 M NaClO4 at 25°C by polarographic technique.The kinetic parameters like transfer coefficient(a),degree of irreversibility(lambda),diffusion coefficient(D)and rate constant(k),were determined.The rate constants(it)that varied from 3.61 cm s~(-1)to 9.93 cm s~(-1)confirmed the quasi-reversible nature of electrode processes.The study was carried out at 25 deg C and 35°C.Thermodynamic parameters such as entropy change(AS),enthalpy change(DELTA H)and free energy change(DELTA G)were determined.The values of stability constants(log beta)that varied from 1.75 to 9.13 showed these drugs or their complexes might be effective against Mn toxicity.