Effect of methanol extracts of red colored rices on antioxidant activity and growth inhibitory activities of cancer cells.

摘要

The inhibitory effects of water and methanol extracts of Jakwangdo and Honghyangmi rices, which have a red pericarp, on rat microsome lipid peroxidation and growth of 4 human cancer cells (HepG2 (liver cancer), SNU-1 (stomach cancer), MCF-7 (breast cancer) and SNU-C4 (colon cancer)) were examined. Methanol extracts of the rices showed antioxidative activity and growth inhibition effects on cancer cells. However, water extracts did not show either action. Inhibitory activities of methanol extracts of Jakwangdo and Honghyangmi rice against lipid peroxidation of rat microsome was 80% and 68%, respectively, at a concn. of 1 mg/assay. Jakwangdo methanol extracts showed the highest growth inhibitory activity in MCF-7 cells among the cancer cells tested. Methanol extracts of the red colored rices were further fractionated with hexane, chloroform, ethyl acetate and butanol. Both chloroform and hexane fractions showed strong growth inhibitory activity in HepG2 and MCF-7 cells.