Resolution of Overlapped Capillary Electrophoresis Peaks by Using Heuristic Evolving Latent Projections to Quantify Chloroquine Phosphate and Promethazine Hydrochloride

摘要

Chloroquine phosphate and promethazine hydrochloride are two main components in compound re-serpine tablets. It is difficult to separate the two compounds with capillary electrophoresis (CE) Heuristic evolving latent projections (HELP) is a chemometric algorithm which is suitable for resolving overlapped peaks from CE and HPLC. In this paper, HELP was applied to resolving the completely overlapped peaks of chloroquine phosphate and promethazine hydrochloride from CE. Mathematical separation/and satisfactory quantification results can be achieved easily without too much time involved in the procedure.