SYNTHESIS AND BIOLOGICAL ACTIVITY OF CERTAIN (5Z)-5-SUBSTITUTED BENZYLIDENE-2- (3-NITROPHENYL)-3-[5-(3, 5-DINITROPHENYL)-1, 3, 5- THIADIAZOL-2-YL]-3, 5-DIHYDRO-4H-IMIDAZOL-4-ONE AND 1-{[5-(3, 5- DINITROPHENYL)-1, 3, 4-THIADIAZOL-2-YL] DIAZENYL}-2-SUBSTITUTED NAPHTHOL DERIVATIVES

摘要

Imidazole derivatives have interesting pharmaceutical uses such as selective modulators of brady-kinin B2 receptors, useful in the diagnosis and treatment of renal diseases, heart failure etc.Imidazolones have been also found to be associated with several other important pharmacological activities. Thiadiazole nucleus that incorporates an N-C-S linkage exhibits large number of biological activities such as anti-tubercular, antifungal, antibacterial, anti-inflammatory, antiviral etc. Azodyes are well known for their antiseptic activity. Moreover azo compounds have been extensively used in the therapy of helminthiasis. Some of compounds containing azo group are described active against tumors.