A short and efficient regioselective approach to the C-6 to C-19 segment of bifurcaranes and a formal total synthesis of #beta#-microbiotene, microbiotol and cyclocuparanol

摘要

Employing an epoxide rearrangement based ring contraction reaction, a short and efficient regioselective approach to the C-6 to C-19 segment of the toluquinol substituted diterpenes bifurcaranes, and its extension to a formal total synthesis of the sesquiterpenes (+-)-#beta#-microbiotene, (+-)-microbiotol and (+-)-cyclocuparanol are described.